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CD4 (Chimeric) Antibody
SPA-02005
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | CD4 |
| Gene Abbr. | CD4 |
| Gene ID | 920 |
| Full Name | CD4 molecule |
| Alias | CD4mut |
| Introduction | Cluster of Differentiation 4 (CD4) is a glycoprotein composed of an amino-terminal extracellular domain (four domains: D1-D4 with Ig-like structures), a transmembrane part, and a short cytoplasmic tail. CD4 is expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic cells, and plays an important role in the development and activation of T cells. On T cells, CD4 is the co-receptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC). Specifically, the D1 domain of CD4 interacts with the β2-domain of the MHC class II molecule. CD4 ensures specificity of the TCR–antigen interaction, prolongs the contact between the T cell and the antigen presenting cell, and recruits the tyrosine kinase Lck, which is essential for T cell activation. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone No. | MT310 |
| Isotype | IgG Kappa |
| Immunogen | CD4. |
| Usage | |
|---|---|
| Application | WB, FC, IHC, IP, IF |
| Dilutions | Western Blot (1:100-1:2000); Flow Cytometry (1:10-1:1000); Immunoprecipitation (1:10-1:500); Immunofluorescence (1:10-1:500) |
| Reactivity | Human, Primate-Cynomolgus Monkey, Rhesus Macaque |
| Specificity | mt310 binds to the extracellular domain D1 of CD4 -the same site as the HIV-1 gp120-binding site. |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS. |
| Preservative | 0.02% Proclin 300 |
| Storage Temp. | Store at 4 °C for up to 3 months. For longer storage, aliquot and store at -20 °C. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.