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CD27/TNFRSF7 Antibody
SPA-01888
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | CD27 |
| Gene Abbr. | CD27 |
| Gene ID | 939 |
| Full Name | CD27 molecule |
| Alias | S152, S152. LPFS2, T14, TNFRSF7, Tp55 |
| Introduction | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq] |
| Product Details | |
|---|---|
| Host | Goat |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | S. frugiperda insect ovarian cell line Sf 21-derived recombinant human CD27. Thr21-Ile192. Accession # P26842. |
| Usage | |
|---|---|
| Application | WB, FC, IHC |
| Dilutions | Western Blot (1 µg/mL); Flow Cytometry (0.25 µg/10^6 cells); Immunohistochemistry (3-15 µg/mL); Neutralization (2.25-9.0 µg/mL) |
| Reactivity | Human |
| Specificity | Detects human CD27 in direct ELISAs and Western Blots. In direct ELISAs, approximately 25% cross-reactivity with recombinant mouse CD27 is observed and less than 1% cross-reactivity with recombinant human (rh) CD30, rh4-1BB, rhCD40, rhDR3, rhDR6, rhFas, rhGITR, rhHVEM, rhRANK, rhNGF R, rhsTNF RI, and rhsTNF RII is observed. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.