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CD11α/ITGAL (Chimeric) Antibody
SPA-06193
| Size | Price |
| 0.025 mg | Online Inquiry |
| 0.2 mg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | Integrin |
| Gene Abbr. | ITGAL |
| Gene ID | 3683 |
| Full Name | integrin subunit alpha L |
| Alias | CD11A, LFA-1, LFA1A |
| Introduction | CD11α, also known as integrin alpha-L (ITGAL), is the alpha chain of the lymphocyte function-associated antigen-1 (LFA-1). CD11α combines with the beta chain CD18 (ITGB2) to form LFA-1, an integrin expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands ICAM-1, 2, 3, and 4 F11R/JAM-1, and the secreted form of ubiquitin-like protein ISG15. LFA-1 is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction and transmigration, cytotoxic T cell co-stimulation cytotoxic NK cell mediated killing leukocyte clearance and antibody-dependent killing by granulocytes and monocytes. LFA-1 is required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis. High expression of CD11α has been associated with antigen-specific and tumor-reactive T cells. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone No. | hu1124 |
| Isotype | IgG Kappa |
| Immunogen | Efalizumab binds to CD11a, a subunit of leukocyte function antigen-1 (LFA-1), which is expressed on all leukocytes. |
| Usage | |
|---|---|
| Application | FC, IHC |
| Dilutions | Flow Cytometry (1:10-1:1000) |
| Reactivity | Human |
| Specificity | Binds to human LFA-1. |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS. |
| Preservative | 0.02% Proclin 300 |
| Storage Temp. | Store at 4 °C for up to 3 months. For longer storage, aliquot and store at -20 °C. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.