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CD11b/ITGAM Antibody
SPA-06223
| Size | Price |
| 100 µg | Online Inquiry |
| 25 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | Integrin |
| Gene Abbr. | ITGAM |
| Gene ID | 3684 |
| Full Name | integrin subunit alpha M |
| Alias | CD11B, CR3A, MAC-1, MAC1A, MO1A |
| Introduction | Cluster of differentiation molecule 11b (CD11b)/Integrin alpha M (ITGAM) is a transmembrane protein forming heterodimers that are composed of α and β subunits. CD11b is expressed by, and commonly used as a marker for, myeloid lineage cells, including neutrophils, monocytes, macrophages, and microglia. CD11b is phosphorylated at Ser1126 (cytoplasmic tail) in neutrophils. Research has shown that this phosphorylation event plays a role for leukocytes traveling from the blood stream to tissues. Furthermore, genome-wide association studies have linked CD11b to autoimmune diseases, such as systemic lupus erythematous (SLE). |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | ITGAM/3340 |
| Isotype | IgG2A Kappa |
| Immunogen | This antibody was immunized from recombinant fragment (around aa941-1074) of human ITGAM protein (exact sequence is proprietary). |
| Usage | |
|---|---|
| Application | WB, IHC |
| Dilutions | Western Blot (1-2 µg/mL); Immunohistochemistry (1-2 µg/mL) |
| MW(KDa) | 170 |
| Reactivity | Human |
| Storage & Handling | |
|---|---|
| Storage Buffer | 10 mM PBS with 0.05% BSA. |
| Preservative | 0.05% Sodium Azide |
| Storage Temp. | Store at 4 °C. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.