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CD11b/ITGAM Antibody
SPA-06220
| Size | Price |
| 100 µg | Online Inquiry |
| 25 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | Integrin |
| Gene Abbr. | ITGAM |
| Gene ID | 3684 |
| Full Name | integrin subunit alpha M |
| Alias | CD11B, CR3A, MAC-1, MAC1A, MO1A |
| Introduction | Cluster of differentiation molecule 11b (CD11b)/Integrin alpha M (ITGAM) is a transmembrane protein forming heterodimers that are composed of α and β subunits. CD11b is expressed by, and commonly used as a marker for, myeloid lineage cells, including neutrophils, monocytes, macrophages, and microglia. CD11b is phosphorylated at Ser1126 (cytoplasmic tail) in neutrophils. Research has shown that this phosphorylation event plays a role for leukocytes traveling from the blood stream to tissues. Furthermore, genome-wide association studies have linked CD11b to autoimmune diseases, such as systemic lupus erythematous (SLE). |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | Rabbit Polyclonal CD11b Antibody was made to a synthetic peptide made to an internal region (within residues 250-350) of the mouse CD11b protein. [Swiss-Prot# P05555]. |
| Usage | |
|---|---|
| Application | WB, FC, IF, IHC, ISH |
| Dilutions | Western Blot (2 µg/mL); Flow Cytometry (1:10-1:1000); Immunofluorescence (1:200); Immunohistochemistry (1:400) |
| MW(KDa) | 170 |
| Reactivity | Human, Mouse, Rat, Bovine, C. elegans, Chinese Hamster, Primate, Rhesus Macaque |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS. |
| Preservative | 0.02% Sodium Azide |
| Storage Temp. | Aliquot and store at -20 °C or -80 °C. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.