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CCL5/RANTES Antibody
SPA-01689
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | CCL5/RANTES |
| Gene Abbr. | CCL5 |
| Gene ID | 6352 |
| Full Name | C-C motif chemokine ligand 5 |
| Alias | D17S136E, RANTES, SCYA5, SIS-delta, SISd |
| Introduction | RANTES is a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. It binds to CCR1, CCR3, CCR4 and CCR5 and is one of the major HIV suppressive factors produced by CD8+ T cells. Recombinant RANTES protein induces a dose dependent inhibition of different strains of HIV 1, HIV 2, and simian immunodeficiency virus (SIV). It is T cell and macrophage specific, induced by mitogens, and belongs to the intercrine beta (chemokine CC) family. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 676117 |
| Isotype | IgG2B |
| Immunogen | E. coli-derived recombinant canine CCL5/RANTES. Ser24-Ser91. Q8HYS0. |
| Usage | |
|---|---|
| Application | Neutralization |
| Dilutions | Neutralization (0.075-0.45 µg/mL) |
| Reactivity | Canine |
| Specificity | Detects canine CCL5/RANTES in direct ELISAs. In Western Blots, no cross-reactivity with recombinant cotton rat CCL5, recombinant feline CCL5, recombinant human (rh) CCL5, 17, 18, recombinant mouse (rm) CCL5, 7, or 18 is observed. In direct ELISAs, approximately 25% cross‑reactivity with recombinant human CCL5 and no cross-reactivity with recombinant CCL5 from cotton rat, cat, or mouse is observed. No cross-reactivity with rhCCL1, 4, 11, 14, 16, 21, 23, 24, 26, 27, rmCCL6, 11, 21, 24, 26, or 27 is observed. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.