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CCL15/MIP-1 delta Antibody
SPA-01532
| Size | Price |
| 25 µg | Online Inquiry |
| 500 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | CCL15/MIP-1 delta |
| Gene Abbr. | CCL15 |
| Gene ID | 6359 |
| Full Name | C-C motif chemokine ligand 15 |
| Alias | HCC-2, HMRP-2B, LKN-1, LKN1, MIP-1 delta |
| Introduction | CCL15, a human CC chemokine, was isolated from a human fetal spleen cDNA library. CCL15 cDNA encodes a predicted 113 amino acid (aa) protein containing a putative signal peptide of 21 aa that is cleaved to generate a 92 aa residue mature protein. Within the CC family members, human CCL15 shares 45%, 44%, 35%, and 30% aa homology with mouse C10, human MPIF-1, human HCC-1, and mouse MIP-1 gamma, respectively. The gene for MIP-1δ is found on chromosome 17 where the genes for most of the human CC chemokines are located. Human CCL15 is expressed in T and B lymphocytes, NK cells, monocytes and monocyte-derived dendritic cells. Human MIP-1δ is chemotactic for T cells and monocytes and has been shown to induce calcium flux in human CCR-1-transfected cells. |
| Product Details | |
|---|---|
| Host | Goat |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | E. coli-derived recombinant human CCL15/MIP-1δ. Ser46-Ile113. Q16663. |
| Usage | |
|---|---|
| Application | WB |
| Dilutions | Western Blot (0.1 µg/mL); Neutralization (0.5-2.5 µg/mL) |
| Reactivity | Human |
| Specificity | Detects human CCL15/MIP‑1δ in direct ELISAs and Western Blots. In direct ELISAs and Western Blots, a preference for the 68 aa residue isoform over the 92 aa residue isoform of human CCL15/LKN-1 is shown. Additionally, in direct ELISAs, less than 1% cross-reactivity with with rh6Ckine, rhBLC/BCA1, rhENA78, rhEotaxin, rhEotaxin2, rhFractalkine, rhGCP2, rhGRO alpha, rhGRO beta, rhGRO gamma, rhHCC1, rhHCC4, rhI309,rhIL8, rhMCP1, rhMCP2, rhMCP3, rhMCP4, rhMDC, rhMIG, rhMIP1 alpha, rhMIP1 beta, rhMIP3 alpha, rhMIP3 beta, rhMPIF1, rhNAP2, rhPARC, rhRANTES, rhSDF1 alpha,rhSDF1 beta,rhTarc, rhTECK, and rhVIC is observed. Neutralizes the biological activity of the 68 aa isoform of recombinant human (rh) CCL15/LKN-1. It will also neutralize the biological activity of the 92 aa residue isoform of rhCCL15/LKN-1 using a 2-fold higher Ig concentration. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.