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Caspase-3 Antibody
SPA-01391
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | Caspase-3 |
| Gene Abbr. | CASP3 |
| Gene ID | 836 |
| Full Name | caspase 3 |
| Alias | CPP32, CPP32B, SCA-1 |
| Introduction | Caspase-3 (CPP-32, Apoptain, Yama, SCA-1) is a critical executioner of apoptosis, as it is either partially or totally responsible for the proteolytic cleavage of many key proteins, such as the nuclear enzyme poly (ADP-ribose) polymerase (PARP). Activation of caspase-3 requires proteolytic processing of its inactive zymogen into activated p17 and p12 fragments. Cleavage of caspase-3 requires the aspartic acid residue at the P1 position. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | This Caspase-3 Antibody was developed against a synthetic peptide mapping to the N-terminus adjacent to the cleavage site of human caspase-3. |
| Usage | |
|---|---|
| Application | WB, IHC |
| Dilutions | Western Blot (1:50-1:500); Immunohistochemistry (1:10-1:20) |
| MW(KDa) | 17, 19, 35 |
| Reactivity | Human, Mouse, Rat |
| Specificity | The preferentially recognizes the p17 fragment of the active Caspase 3. |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS (pH 7.2), 5 mM EDTA, 0.5% BSA, 30% Glycerol. |
| Preservative | 0.03% Proclin |
| Storage Temp. | Aliquot and store at -20 °C or -80 °C. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.