Online Inquiry
CASP4 cDNA ORF Clone, Human, In cloning vector
SPD-02328
| Size | Price |
| 1 Unit | Online Inquiry |
| Description |
|---|
| Full length Clone DNA of Human caspase 4, apoptosis-related cysteine peptidase, transcript variant alpha. |
| Target Information | |
|---|---|
| Species | Human |
| Target Name | Caspase-4 |
| Gene Abbr. | CASP4 |
| Gene ID | 837 |
| Full Name | caspase 4 |
| Alias | ICE(rel)II, ICEREL-II, ICH-2, Mih1, Mih1/TX |
| Introduction | Caspase-4 (TX/ICH-2/ICErelII) is a member of the caspase family of proteases that play a key role in the execution of apoptosis and activation of inflammatory cytokines. Expression of caspase-4 has been observed in most tissues except brain, with highest levels in placenta, lung, spleen, and peripheral blood lymphocytes (PBL). Caspase-4 was originally found to contribute to Fas-mediated apoptosis. Several caspases (including caspase-4, caspase-5, and mouse caspase-11 and -12) are most closely related to caspase-1 and are capable of inducing apoptosis when over-expressed but are better characterized in the proteolytic activation of inflammatory cytokines. Caspase-4 associates with TRAF6 and is involved in the LPS inducible production of inflammatory cytokines IL-8 and MIP1 in THP-1 cells. While caspase-4 and mouse caspase-12 localize to the endoplasmic reticulum (ER) and may be activated by drugs that induce ER-stress at least one study suggests that caspase-4 and caspase-12 are not essential for the ER-stress induced apoptosis. |
| Product Details | |
|---|---|
| Description | Full length Clone DNA of Human caspase 4, apoptosis-related cysteine peptidase, transcript variant alpha. |
| NCBI Ref Seq | NM_001225.3 |
| RefSeq ORF Size | 1134 bp |
| Sequence Information | Identical with the Gene Bank Ref. ID sequence except for two point mutations: 6 A/T and 858 A/G not causing the amino acid variation. |
| Vector | pMD18-T Simple Vector |
| Quality Control | The plasmid is confirmed by full-length sequencing. |
| Storage | The lyophilized plasmid can be stored at ambient temperature for three months. |
| Usage | |
|---|---|
| Sequencing Primers | M13-47 and RV-M |
| Antibiotic in E.coli | Ampicillin |
| Shipping | Each tube contains lyophilized plasmid. |
| Storage | The lyophilized plasmid can be stored at ambient temperature for three months. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.