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c-IAP1/HIAP-2 Antibody
SPA-01199
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | c-IAP1 |
| Gene Abbr. | BIRC2 |
| Gene ID | 329 |
| Full Name | baculoviral IAP repeat containing 2 |
| Alias | API1, HIAP2, Hiap-2, MIHB, RNF48 |
| Introduction | The inhibitor of apoptosis protein (IAP) family consists of an evolutionarily conserved group of apoptosis inhibitors containing a conserved 70 amino acid BIR (baculovirus inhibitor repeat) domain. Human members of this family include c-IAP1, c-IAP2, XIAP, survivin, livin, and NAIP. Overexpression of IAP family members, particularly survivin and livin, in cancer cell lines and primary tumors suggests an important role for these proteins in cancer progression. In general, the IAP proteins function through direct interactions to inhibit the activity of several caspases, including caspase-3, caspase-7, and caspase-9. In addition, binding of IAP family members to the mitochondrial protein Smac blocks their interaction with caspase-9, thereby allowing the processing and activation of the caspase. |
| Product Details | |
|---|---|
| Host | Goat |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | E. coli-derived recombinant human cIAP-1/HIAP-2. His2-Ser618. Q13490. |
| Usage | |
|---|---|
| Application | WB, IHC |
| Dilutions | Western Blot (0.5 µg/mL); Immunohistochemistry (5-15 µg/mL) |
| MW(KDa) | 62 |
| Reactivity | Human |
| Validation | Knockout Validated. |
| Specificity | Detects human cIAP-1/HIAP-2. Does not cross-react with recombinant human cIAP-2 or XIAP. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.