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Brilanestrant (GDC-0810)
SPC-00446
CAS No. 1365888-06-7
| Size | Price |
| 5 mg | Online Inquiry |
| 25 mg | Online Inquiry |
| Bulk Size | Online Inquiry |
Estrogen/progestogen Receptor antagonist
| Description |
|---|
| Brilanestrant (GDC-0810, ARN-810） is a potent ER-α binder (ER-α, IC50 = 6.1 nM; ER-β, IC50 = 8.8 nM), a full transcriptional antagonist with no agonism and displays good potency and efficacy in ER-α degradation (EC50 = 0.7 nM) and MCF-7 breast cancer cell viability (IC50 = 2.5 nM) assays with good selectivity over other nuclear hormone receptors. |
| Product Details | |
|---|---|
| CAS No. | CAS No. 1365888-06-7 |
| Description | Brilanestrant (GDC-0810, ARN-810） is a potent ER-α binder (ER-α, IC50 = 6.1 nM; ER-β, IC50 = 8.8 nM), a full transcriptional antagonist with no agonism and displays good potency and efficacy in ER-α degradation (EC50 = 0.7 nM) and MCF-7 breast cancer cell viability (IC50 = 2.5 nM) assays with good selectivity over other nuclear hormone receptors. |
| Formula | C26H20ClFN2O2 |
| Molecular Weight | 446.90 |
| Storage | 3 years -20°C powder 2 years -80°C in solvent |
| Synonyms | ARN-810 |
| SMILES | CCC(=C(C1=CC=C(C=C1)C=CC(=O)O)C2=CC3=C(C=C2)NN=C3)C4=C(C=C(C=C4)F)Cl |
| Usage | |
|---|---|
| Storage | 3 years -20°C powder 2 years -80°C in solvent |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.