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BRD8 Antibody
SPA-01144
| Size | Price |
| 100 µL | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | BRD8 |
| Gene Abbr. | BRD8 |
| Gene ID | 10902 |
| Full Name | bromodomain containing 8 |
| Alias | SMAP, SMAP2, p120 |
| Introduction | BRD8 may act as a coactivator during transcriptional activation by hormone activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | The immunogen recognized by this antibody maps to a region between residues 200 and 250 of human Bromodomain containing 8 using the numbering given in TrEMBL entry Q969M9 (GeneID 10902). |
| Usage | |
|---|---|
| Application | WB, IHC, IP |
| Dilutions | Western Blot (1:10000-1:25000); Immunohistochemistry (1:10-1:500); Immunoprecipitation (2-8 μg/mg lysate) |
| Reactivity | Human |
| Storage & Handling | |
|---|---|
| Storage Buffer | Tris-Citrate/Phosphate (pH 7.0-8.0). |
| Preservative | 0.09% Sodium Azide |
| Storage Temp. | Store at 4 °C. |
| Handling | Do not freeze. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.