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Bosutinib (SKI-606)
SPC-00435
CAS No. 380843-75-4
| Size | Price |
| 10 mM (1 mL in DMSO) | Online Inquiry |
| 10 mg | Online Inquiry |
| 50 mg | Online Inquiry |
| 100 mg | Online Inquiry |
| Bulk Size | Online Inquiry |
Src inhibitor ; ERK inhibitor ; S6 Kinase inhibitor ; STAT inhibitor ; Bcr-Abl inhibitor ; Autophagy activator
| Description |
|---|
| Bosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy. |
| Product Details | |
|---|---|
| CAS No. | CAS No. 380843-75-4 |
| Description | Bosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy. |
| Formula | C26H29Cl2N5O3 |
| Molecular Weight | 530.45 |
| Storage | 3 years -20°C powder 2 years -80°C in solvent |
| Synonyms | N/A |
| SMILES | CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC |
| Solubility | DMSO |
| Usage | |
|---|---|
| Storage | 3 years -20°C powder 2 years -80°C in solvent |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.