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BMP-2 Antibody
SPA-01086
| Size | Price |
| 0.025 mL | Online Inquiry |
| 0.1 mL | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | BMP-2 |
| Gene Abbr. | BMP2 |
| Gene ID | 650 |
| Full Name | bone morphogenetic protein 2 |
| Alias | BDA2, BMP2A, SSFSC |
| Introduction | Bone morphogenic protein 2 is required for effective healing of fractures in bone. It is necessary for the expression of transcription factors that regulate osteogenesis and differentiation of progenitor cells into mature osteoblasts. Embryologically, BMP2 is important in mesenchymal maturation to fetal valves. The same mechanism of maturation is also utilized by tumor molecular machinery once mesenchymal stem cells are recruited to tumor microenvironments, leading to many recent attempts to generate BMP inhibitors in the treatment of ovarian and colon cancer. The activity of BMP2 is antagonized by the activity of Bambi and Crim1. BMP2 is an interesting target for distinguishing the mechanism by which normal and necessary maturation processes are mutated in tumorigenesis. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 100221 |
| Isotype | IgG2B |
| Immunogen | Chinese hamster ovary cell line CHO-derived recombinant human BMP-2. Gln283-Arg396. Accession # P12643. |
| Usage | |
|---|---|
| Application | WB, ELISA |
| Dilutions | Western Blot (1 µg/mL); ELISA Capture (2-8 µg/mL); ELISA Detection (0.5-2.0 µg/mL) |
| Reactivity | Human |
| Specificity | Detects human BMP-2 in ELISAs and Western Blots. In Western Blots, this antibody shows less than 1% cross-reactivity with recombinant human (rh) BMP‑3, rhBMP-4, rhBMP-5, rhBMP-6, or rhBMP-7. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.