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BIO
SPC-00399
CAS No. 667463-62-9
| Size | Price |
| 10 mg | Online Inquiry |
| 50 mg | Online Inquiry |
| Bulk Size | Online Inquiry |
GSK-3 inhibitor ; JAK inhibitor ; CDK inhibitor ; Apoptosis related activator
| Description |
|---|
| BIO is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β in a cell-free assay, shows >16-fold selectivity over CDK5, also a pan-JAK inhibitor with IC50 of 30 nM for Tyk2. BIO induces apoptosis in human melanoma cells. |
| Product Details | |
|---|---|
| CAS No. | CAS No. 667463-62-9 |
| Description | BIO is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β in a cell-free assay, shows >16-fold selectivity over CDK5, also a pan-JAK inhibitor with IC50 of 30 nM for Tyk2. BIO induces apoptosis in human melanoma cells. |
| Formula | C16H10BrN3O2 |
| Molecular Weight | 356.17 |
| Storage | 3 years -20°C powder 2 years -80°C in solvent |
| Synonyms | GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime |
| SMILES | C1=CC=C2C(=C1)C(=C(N2)C3=C(NC4=C3C=CC(=C4)Br)O)N=O |
| Usage | |
|---|---|
| Storage | 3 years -20°C powder 2 years -80°C in solvent |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.