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Bax Antibody
SPA-00913
| Size | Price |
| 30 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | BAX |
| Gene Abbr. | BAX |
| Gene ID | 581 |
| Full Name | BCL2 associated X, apoptosis regulator |
| Alias | BCL2L4 |
| Introduction | Bax is a key component for cellular induced apoptosis through mitochondrial stress. Upon apoptotic stimulation, Bax forms oligomers and translocates from the cytosol to the mitochondrial membrane. Through interactions with pore proteins on the mitochondrial membrane, Bax increases the membrane's permeability, which leads to the release of cytochrome c from mitochondria, activation of caspase-9 and initiation of the caspase activation pathway for apoptosis. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 127606 |
| Isotype | IgG2B |
| Immunogen | E. coli-derived recombinant human Bax aa 1-171. Q07812. |
| Usage | |
|---|---|
| Application | WB, IF |
| Dilutions | Western Blot (1 µg/mL); Immunofluorescence (8-25 µg/mL) |
| MW(KDa) | 20 |
| Reactivity | Human |
| Validation | Knockout Validated. |
| Specificity | Detects full-length human Bax in Western Blots. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.