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Bak Antibody
SPA-00882
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | Bak |
| Gene Abbr. | BAK1 |
| Gene ID | 578 |
| Full Name | BCL2 antagonist/killer 1 |
| Alias | BAK, BAK-LIKE, BCL2L7, CDN1 |
| Introduction | Bak is a proapoptotic member of the Bcl-2 family. This protein is located on the outer membrane of mitochondria and is an essential component for transduction of apoptotic signals through the mitochondrial pathway. Upon apoptotic stimulation, an upstream stimulator like truncated BID (tBID) induces conformational changes in Bak to form oligomer channels in the mitochondrial membrane for cytochrome c release. The release of cytochrome c to the cytosol activates the caspase-9 pathway and eventually leads to cell death. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 38E2 |
| Isotype | IgG2A Kappa |
| Immunogen | Recombinant human BAK (29-187aa) purified from E.coli. |
| Usage | |
|---|---|
| Application | WB, ELISA, FC, IF |
| Dilutions | Western Blot (1:250-500); ELISA (1:100-1:2000); Immunofluorescence (1:250-500) |
| MW(KDa) | 25 |
| Reactivity | Human |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS (pH 7.4), 10% Glycerol. |
| Preservative | 0.02% Sodium Azide |
| Storage Temp. | Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.