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BAFF/BLyS/TNFSF13B Antibody
SPA-00848
| Size | Price |
| 0.05 mg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | BAFF |
| Gene Abbr. | TNFSF13B |
| Gene ID | 10673 |
| Full Name | TNF superfamily member 13b |
| Alias | BAFF, BLYS, CD257, DTL, TALL-1 |
| Introduction | Simultaneously four different laboratories identified a new member of the tumor necrosis factor (TNF) family. This has been named as TALL-1, THANK (TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase, BAFF (for B cell activating factor belonging to the TNF family) and BLyS (B lymphocyte stimulator). Membrane-bound BLyS (BAFF) is processed and secreted through the action of a protease whose specificity matches that of the furin family of proprotein convertases. Secreted BLyS (BAFF) acts as a potent B cell growth factor. This protein is expressed abundantly in peripheral blood lymphocytes, specifically in monocytes and macrophages. BLyS (BAFF) regulation is upregulated by interferon gamma. Overexpression of BLyS (BAFF) in transgenic mice lead to increased numbers of mature B and effector T cells. These mice also develop autoimmune -like symptoms, such as high levels of rheumatoid factors, anti-DNA autoantibodies, etc.. Two receptors for BLyS (BAFF) have been identified and termed as BCMA and TACI. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | A peptide corresponding to 16 amino acids near the carboxy terminus of human BAFF/BLyS/TNFSF13B. The immunogen is located within the last 50 amino acids of BAFF/BLyS/TNFSF13B. Amino Acid Sequence: EEGDELQLAIPRENAQ. |
| Usage | |
|---|---|
| Application | WB, ELISA, IF, IHC |
| Dilutions | Western Blot (0.25-1 µg/mL); ELISA (1:100-1:2000); Immunofluorescence (1-20 µg/mL) |
| Reactivity | Human, Mouse, Rat |
| Specificity | Human BAFF/BLyS/TNFSF13B has 3 isoforms, including isoform 1 (285aa, 31kD), isoform 2 (266aa, 29kD) and isoform 3 (164aa, 17.6kD). Mouse BAFF/BLyS/TNFSF13B has 2 isoforms, including isoform 1 (309aa, 34kD) and isoform 2 (290aa, 32kD). Rat BAFF/BLyS/TNFSF13B has only one isoform (274aa, 30kD). This antibody can detect two longer human isoforms, mouse and rat. |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS. |
| Preservative | 0.02% Sodium Azide |
| Storage Temp. | Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.