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Aurora A/AIK Antibody
SPA-00783
| Size | Price |
| 25 µL | Online Inquiry |
| 0.1 mL | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | Aurora A/AIK |
| Gene Abbr. | AURKA |
| Gene ID | 6790 |
| Full Name | aurora kinase A |
| Alias | AIK, ARK1, AURA, BTAK, PPP1R47 |
| Introduction | Aurora A (AIK) is a cell cycle-regulated Ser/Thr protein kinase that is overexpressed in many tumor cell lines. Phosphorylation of Aurora A at Thr288 within the kinase activation loop results in a significant increase in its activity and may target the protein for proteasomal degradation during mitosis. The closely-related kinase Aurora B (AIM1) has been implicated in multiple mitotic events and siRNA silencing of Aurora B expression results in reduced histone H3 phosphorylation, aberrant chromosome alignment/segregation, and altered survivin localization. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Immunogen | Synthetic peptide corresponding to the amino terminus of human Aurora A/AIK. |
| Source/Purification | Antibodies are produced by immunizing animals with a synthetic peptide corresponding to the amino terminus of human Aurora A/AIK. Antibodies are purified by protein A and peptide affinity chromatography. |
| Usage | |
|---|---|
| Application | WB |
| Dilutions | Western Blot (1:1000) |
| MW(KDa) | 48 |
| Reactivity | Human, Monkey |
| Sensitivity | Endogenous |
| Specificity | It detects endogenous levels of total Aurora A/AIK protein. The antibody may cross-react with AIK3. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA and 50% glycerol. |
| Preservative | No Preservative |
| Storage Temp. | Store at -20 °C. |
| Handling | Do not aliquot the antibody. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.