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AT406 (SM-406)
SPC-00246
CAS No. 1071992-99-8
| Size | Price |
| 10 mM (1 mL in DMSO) | Online Inquiry |
| 5 mg | Online Inquiry |
| 25 mg | Online Inquiry |
| 200 mg | Online Inquiry |
| Bulk Size | Online Inquiry |
IAP antagonist ; E3 Ligase inhibitor
| Description |
|---|
| AT406 (SM-406, ARRY-334543, Debio1143) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide. Phase 1. |
| Product Details | |
|---|---|
| CAS No. | CAS No. 1071992-99-8 |
| Description | AT406 (SM-406, ARRY-334543, Debio1143) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide. Phase 1. |
| Formula | C32H43N5O4 |
| Molecular Weight | 561.71 |
| Storage | 3 years -20°C powder 2 years -80°C in solvent |
| Synonyms | ARRY-334543, Debio1143 |
| SMILES | CC(C)CC(=O)N1CCC2CCC(N2C(=O)C(C1)NC(=O)C(C)NC)C(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4 |
| Solubility | DMSO |
| Usage | |
|---|---|
| Storage | 3 years -20°C powder 2 years -80°C in solvent |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.