Aprepitant - CD BioSciences

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Aprepitant

Aprepitant

SPC-00218

Aprepitant

CAS No. 170729-80-3

Size Price
10 mM (1 mL in DMSO) Online Inquiry
5 mg Online Inquiry
10 mg Online Inquiry
25 mg Online Inquiry
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Neurokinin Receptor antagonist ; Interleukins inhibitor ; TNF-alpha inhibitor ; CSF-1R inhibitor ; Anti-infection inhibitor

Description
Aprepitant (MK-0869, L-754030) is a potent and selective neurokinin-1 receptor antagonist with IC50 of 0.1 nM. Aprepitant reduces levels of pro-inflammatory cytokines including G-CSF, IL-6, IL-8 and TNFα. Aprepitant inhibits HIV infection of human macrophages.
Product Details
CAS No. CAS No. 170729-80-3
Description Aprepitant (MK-0869, L-754030) is a potent and selective neurokinin-1 receptor antagonist with IC50 of 0.1 nM. Aprepitant reduces levels of pro-inflammatory cytokines including G-CSF, IL-6, IL-8 and TNFα. Aprepitant inhibits HIV infection of human macrophages.
Formula C23H21F7N4O3
Molecular Weight 534.43
Storage 3 years -20°C powder
2 years -80°C in solvent
Synonyms MK-0869, L-754030
SMILES CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC2C(N(CCO2)CC3=NNC(=O)N3)C4=CC=C(C=C4)F
Solubility DMSO
Usage
Storage 3 years -20°C powder
2 years -80°C in solvent

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