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ADAMTS5 Antibody
SPA-00225
| Size | Price |
| 0.1 mL | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | ADAMTS5 |
| Gene Abbr. | ADAMTS5 |
| Gene ID | 11096 |
| Full Name | ADAM metallopeptidase with thrombospondin type 1 motif 5 |
| Alias | ADAM-TS 11, ADAM-TS 5, ADAM-TS5, ADAMTS-11, ADAMTS-5 |
| Introduction | ADAMTS5, also known as aggrecanase-2, is a Metallopeptidase M12B type protease that is responsible for degradation of the articular cartilage protein aggrecan. The protein contains a signal sequence, a prodomain with both a potential cysteine switch and a furin cleavage site, a metalloproteinase domain with a conserved zinc-binding motif and a 'met turn,' a disintegrin-like domain, and a spacer region between a thrombospondin type 1 motif and thrombospondin submotif. At least four transcript variants have been reported. ADAMTS5 has been implicated in inflammatory joint diseases. ADAMTS5 expression has been documented in a range of normal human tissues. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | Synthetic 18 amino acid peptide from Metalloprotease domain of human ADAMTS5. |
| Usage | |
|---|---|
| Application | IHC |
| Reactivity | Human, Mouse, Rat, Canine, Equine, Hamster, Primate, Porcine |
| Specificity | Human ADAMTS5. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS. |
| Preservative | 0.1% Sodium Azide |
| Storage Temp. | Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.