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ADAMTS15 Antibody
SPA-00213
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | ADAMTS15 |
| Gene Abbr. | ADAMTS15 |
| Gene ID | 170689 |
| Full Name | ADAM metallopeptidase with thrombospondin type 1 motif 15 |
| Introduction | ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) is a group of nineteen secreted zinc binding metalloproteases that is involved in development, inflammation, angiogenesis and several pathological conditions. They are synthesized as zymogens which have a pro-domain that is removed by furin-like protein convertases. The mature secreted enzymes consist of catalytic, disintegrin-like, type I thrombospondin (TSP) motif, cysteine-rich, and spacer domains followed by zero to fourteen additional TSP motifs. Among ADAMTS proteases, ADAMTS1, -4, -5, -8, and -15 form a subfamily that possess aggrecanase activity (1 - 3). While ADAMTS4 and -5 (also known as aggrecanse-1 and -2, respectively) have been well studied, the enzymatic activity of ADAMTS15 remains to be explored. It is suggested that ADAMTS15 may be involved in aggrecan degradation and breast cancer. ADAMTS15 may also exhibit tumor suppressor activities since it contains genetic mutations in human colorectal carcinomas and restrains tumor growth and invasion in both in vitro and in vivo studies. The purified rhADAMTS15 is truncated and ends before the spacer domain. |
| Product Details | |
|---|---|
| Host | Sheep |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | Chinese hamster ovary cell line CHO-derived recombinant human ADAMTS15. Gly18-Cys682. Accession # Q8TE58. |
| Usage | |
|---|---|
| Application | WB, IHC, IP |
| Dilutions | Western Blot (1 µg/mL); Immunohistochemistry (5-15 µg/mL); Immunoprecipitation (25 µg/mL) |
| Reactivity | Human, Mouse |
| Specificity | Detects human and mouse ADAMTS15 in direct ELISAs and Western Blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human ADAMTS1, L1.2, L2, 3, 4, 5, 8, 10, 12, 13, and 16 is observed. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.